Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922945 | 0.93 | P2RY12 (0.54) | P2RY12MEN1KMT2AMAPK14MET | |
| SCHEMBL14228581 | 0.90 | P2RY12 (0.42) | P2RY12MEN1KMT2AMAPK14KIT | |
| SCHEMBL12177089 | 0.86 | MEN1 (0.41) | P2RY12MEN1KMT2AMAPK14KIT | |
| SCHEMBL9922733 | 0.86 | P2RY12 (0.50) | P2RY12MEN1KMT2AMAPK14FBP1 | |
| SCHEMBL9922943 | 0.85 | P2RY12 (0.52) | P2RY12MEN1KMT2AMAPK14MET | |
| SCHEMBL14113621 | 0.85 | P2RY12 (0.52) | P2RY12MEN1KMT2AMAPK14MET | |
| SCHEMBL9922343 | 0.85 | P2RY12 (0.51) | P2RY12MEN1KMT2AMETBTK | |
| SCHEMBL12177090 | 0.85 | MAPK14 (0.38) | P2RY12MEN1KMT2AMAPK14KIT | |
| SCHEMBL9923187 | 0.84 | P2RY12 (0.37) | P2RY12MEN1KMT2AMAPK14KIT | |
| SCHEMBL9923183 | 0.84 | P2RY12 (0.38) | P2RY12MEN1KMT2AMAPK14KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |