SCHEMBL13639238

SCHEMBL13639238

CSc1nnc(-c2ccc(OP(=O)(O)O)cc2O)n1-c1cccc2ccccc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.45
HSP90AB1 P08238 1/20 0.45
TLR8 Q9NR97 1/20 0.44
ALDH1A1 P00352 6/20 0.42
GAA P10253 2/20 0.42
KDM4E B2RXH2 1/20 0.42
GLA P06280 1/20 0.42
HSD17B10 Q99714 1/20 0.42
HPGD P15428 3/20 0.41
NPSR1 Q6W5P4 2/20 0.39
RECQL P46063 1/20 0.39
PDE7A Q13946 1/20 0.36
TSHR P16473 3/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
FNTA P49354 1/20 0.35
FNTB P49356 1/20 0.35
MAPT P10636 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2265209 0.85 HSP90AA1 (0.45) HSP90AA1HSP90AB1ALDH1A1GAAKDM4E
SCHEMBL931433 0.84 TLR8 (0.52) HSP90AA1HSP90AB1TLR8ALDH1A1GAA
SCHEMBL8931421 0.75 HSP90AA1 (0.44) HSP90AA1HSP90AB1ALDH1A1GAAKDM4E
SCHEMBL8931412 0.74 HSP90AA1 (0.40) HSP90AA1HSP90AB1TLR8ALDH1A1GAA
SCHEMBL930634 0.72 TLR8 (0.39) HSP90AA1HSP90AB1TLR8ALDH1A1GAA
SCHEMBL930819 0.72 HSP90AA1 (0.50) HSP90AA1HSP90AB1ALDH1A1GAAKDM4E
SCHEMBL12944480 0.72 HSP90AA1 (0.41) HSP90AA1HSP90AB1FNTAFNTB
SCHEMBL4944734 0.71 TSHR (0.46) HSP90AA1HSP90AB1TSHRMAPK1ALOX15
SCHEMBL8931020 0.71 KDM4E (0.48) ALDH1A1KDM4EHSD17B10HPGDTSHR
SCHEMBL12908632 0.71 TLR8 (0.42) HSP90AA1HSP90AB1TLR8ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1817295-B1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP (US) 2012-11-07 EP disclosed