Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.60 |
| ▸ | MDM4 | O15151 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445905 | 1.00 | MDM2 (0.60) | MDM2MDM4TP53 | |
| SCHEMBL18773039 | 1.00 | MDM2 (0.60) | MDM2MDM4TP53 | |
| SCHEMBL7948295 | 0.92 | MDM2 (0.61) | MDM2MDM4TP53 | |
| SCHEMBL7945149 | 0.88 | MDM2 (0.61) | MDM2MDM4TP53 | |
| SCHEMBL2151916 | 0.86 | MDM2 (0.75) | MDM2MDM4TP53 | |
| SCHEMBL2151311 | 0.86 | MDM2 (0.75) | MDM2MDM4TP53 | |
| SCHEMBL7942008 | 0.86 | MDM2 (0.64) | MDM2MDM4TP53 | |
| SCHEMBL7942477 | 0.86 | MDM2 (0.64) | MDM2MDM4TP53 | |
| SCHEMBL18772996 | 0.85 | MDM2 (0.76) | MDM2MDM4TP53 | |
| SCHEMBL7950102 | 0.83 | MDM2 (0.39) | MDM2MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340021-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |