SCHEMBL13639766

SCHEMBL13639766

Bc1cnc(NC(=O)N(C2CCCCC2)C2CCC(c3ccccc3)CC2)s1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CCNE1 P24864 5/20 0.43
CDK2 P24941 5/20 0.43
CDK5 Q00535 5/20 0.43
CDK5R1 Q15078 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.40
OGA O60502 1/20 0.40
HTT P42858 1/20 0.40
DEGS1 O15121 1/20 0.38
ATM Q13315 1/20 0.37
NPC1 O15118 1/20 0.36
TP53 P04637 1/20 0.36
RAB9A P51151 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ACKR3 P25106 1/20 0.36
S1PR1 P21453 1/20 0.35
S1PR3 Q99500 1/20 0.35
HSD11B1 P28845 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2606337 0.88 SMN1; SMN2 (0.43) CCNE1CDK2CDK5CDK5R1SMN1; SMN2
SCHEMBL1000130 0.87 CCNE1 (0.45) CCNE1CDK2CDK5CDK5R1SMN1; SMN2
SCHEMBL2606472 0.83 SMN1; SMN2 (0.40) CCNE1CDK2CDK5SMN1; SMN2HTT
SCHEMBL999706 0.82 CCNE1 (0.41) CCNE1CDK2CDK5CDK5R1SMN1; SMN2
SCHEMBL2650468 0.82 CCNE1 (0.41) CCNE1CDK2CDK5CDK5R1SMN1; SMN2
SCHEMBL2648451 0.82 CCNE1 (0.41) CCNE1CDK2CDK5CDK5R1SMN1; SMN2
SCHEMBL2648454 0.82 CCNE1 (0.41) CCNE1CDK2CDK5CDK5R1SMN1; SMN2
SCHEMBL2606370 0.82 SMN1; SMN2 (0.41) CCNE1CDK2CDK5SMN1; SMN2HTT
SCHEMBL2606372 0.82 SMN1; SMN2 (0.39) CCNE1CDK2CDK5SMN1; SMN2NPC1
SCHEMBL2606356 0.81 S1PR3 (0.40) CCNE1CDK2CDK5SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1723128-B1 HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS NOVO NORDISK AS (DK) 2012-11-07 EP disclosed