Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 20/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12675316 | 0.88 | ERN1 (0.56) | ERN1 | |
| SCHEMBL18717317 | 0.86 | ERN1 (0.79) | ERN1 | |
| SCHEMBL12767131 | 0.85 | ERN1 (1.00) | ERN1 | |
| SCHEMBL12767149 | 0.84 | ERN1 (1.00) | ERN1 | |
| SCHEMBL31061075 | 0.83 | ERN1 (1.00) | ERN1 | |
| SCHEMBL31060853 | 0.83 | ERN1 (1.00) | ERN1 | |
| SCHEMBL12674915 | 0.83 | ERN1 (1.00) | ERN1 | |
| SCHEMBL12767127 | 0.83 | ERN1 (1.00) | ERN1 | |
| SCHEMBL12675807 | 0.83 | ERN1 (0.77) | ERN1 | |
| SCHEMBL13982506 | 0.81 | ERN1 (0.67) | ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150589-A1 | IRE-1A INHIBITORS | MannKind Corporation (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2532643-A1 | IRE-1A Inhibitors | MannKind Corporation (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-2520561-A1 | IRE-1A Inhibitors | MannKind Corporation (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2008154484-A1 | IRE-1A INHIBITORS | MANNKIND CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |