Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363061 | 0.93 | PDE4B (0.45) | PDE4BCHRM3NR3C1WDR5 | |
| SCHEMBL4096862 | 0.93 | PDE4B (0.45) | PDE4BPDE5ACHRM3 | |
| SCHEMBL1363373 | 0.93 | PDE4B (0.48) | PDE4BNR3C1 | |
| SCHEMBL1364935 | 0.93 | PDE4B (0.42) | PDE4BPDE5ACHRM3 | |
| SCHEMBL1364865 | 0.92 | PDE4B (0.44) | PDE4BCHRM3NR3C1 | |
| SCHEMBL1364333 | 0.92 | PDE4B (0.44) | PDE4BCHRM3NR3C1 | |
| SCHEMBL4347593 | 0.92 | PDE4B (0.43) | PDE4BPDE5A | |
| SCHEMBL4352290 | 0.92 | PDE4B (0.43) | PDE4BPDE5A | |
| SCHEMBL1365366 | 0.90 | PDE4B (0.43) | PDE4BCHRM3ROCK2ROCK1 | |
| SCHEMBL1362892 | 0.90 | PDE4B (0.44) | PDE4BPDE5ACHRM3WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067408-B2 | Dual pharmacophores—PDE4-muscarinic antagonistics | GLAXO GROUP LIMITED (GB) | 2011-11-29 | — | — | US | claimed |
| US-8067408-B2 | Dual pharmacophores—PDE4-muscarinic antagonistics | GLAXO GROUP LIMITED (GB) | 2011-11-29 | — | — | US | disclosed |
| US-20090197871-A1 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197871-A1 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics | PDE4B, PDE4A, CHRM4 | PDE4B 1/4885PDE5A 32/4885CHRM3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.