Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 18/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363343 | 1.00 | CHRM3 (0.49) | CHRM3CHRM2CHRM1KCNH2PDE4B | |
| SCHEMBL1364449 | 0.97 | CHRM3 (0.53) | CHRM3CHRM2CHRM1KCNH2 | |
| SCHEMBL1362665 | 0.95 | CHRM3 (0.47) | CHRM3CHRM2CHRM1KCNH2PDE4B | |
| SCHEMBL1362452 | 0.95 | CHRM3 (0.47) | CHRM3CHRM2CHRM1KCNH2PDE4B | |
| SCHEMBL1365318 | 0.95 | CHRM3 (0.48) | CHRM3CHRM2CHRM1KCNH2PDE4B | |
| SCHEMBL1362340 | 0.95 | CHRM3 (0.57) | CHRM3CHRM2CHRM1KCNH2 | |
| SCHEMBL1362628 | 0.95 | CHRM3 (0.57) | CHRM3CHRM2CHRM1KCNH2 | |
| SCHEMBL1364800 | 0.95 | CHRM3 (0.48) | CHRM3CHRM2CHRM1KCNH2PDE4B | |
| SCHEMBL1364679 | 0.94 | PDE4B (0.44) | CHRM3CHRM2CHRM1KCNH2PDE4B | |
| SCHEMBL1364318 | 0.94 | CHRM3 (0.47) | CHRM3CHRM2CHRM1KCNH2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067408-B2 | Dual pharmacophores—PDE4-muscarinic antagonistics | GLAXO GROUP LIMITED (GB) | 2011-11-29 | — | — | US | claimed |