Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 7/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LIG1 | P18858 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 3/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653466 | 0.90 | DAO (0.39) | DAOPKMLIG1HPGDPPARD | |
| SCHEMBL3329372 | 0.90 | DAO (0.39) | DAOPKMLIG1HPGDPPARD | |
| SCHEMBL2653852 | 0.90 | DAO (0.38) | DAOPKMLIG1HPGDKDM4E | |
| SCHEMBL2653853 | 0.90 | DAO (0.38) | DAOPKMLIG1HPGDKDM4E | |
| SCHEMBL12064428 | 0.81 | SMN1; SMN2 (0.34) | KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL3333287 | 0.78 | HDAC3 (0.44) | HPGDPPARDPPARAKDM4EMEN1 | |
| SCHEMBL2654040 | 0.78 | HDAC3 (0.44) | HPGDPPARDPPARAKDM4EMEN1 | |
| SCHEMBL2652496 | 0.77 | HDAC3 (0.40) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL2652492 | 0.77 | HDAC3 (0.40) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL2655771 | 0.76 | PPARD (0.41) | PPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-B1 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | LILLY CO ELI (US) | 2009-10-14 | — | — | EP | disclosed |