Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.46 |
| ▸ | RAF1 | P04049 | 10/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13648401 | 0.91 | GSK3B (0.63) | GSK3BDDR2RAF1KDRMAPK14 | |
| SCHEMBL13648408 | 0.91 | DDR2 (0.52) | GSK3BDDR2RAF1KDRMAPK14 | |
| SCHEMBL13648368 | 0.91 | RET (0.50) | GSK3BDDR2RAF1KDRMAPK14 | |
| SCHEMBL13648287 | 0.90 | DDR2 (0.53) | GSK3BDDR2RAF1KDRMAPK14 | |
| SCHEMBL13648395 | 0.89 | GSK3B (0.51) | GSK3BDDR2RAF1KDRMAPK14 | |
| SCHEMBL13648405 | 0.88 | GSK3B (0.47) | GSK3BDDR2RAF1KDRMAPK14 | |
| SCHEMBL13648441 | 0.87 | GSK3B (0.48) | GSK3BDDR2RAF1KDRMAPK14 | |
| SCHEMBL13648415 | 0.86 | GSK3B (0.45) | GSK3BDDR2RAF1KDRMAPK14 | |
| SCHEMBL13648273 | 0.86 | DDR2 (0.53) | GSK3BDDR2RAF1KDRMAPK14 | |
| SCHEMBL5564720 | 0.86 | GSK3B (0.65) | GSK3BDDR2RAF1KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253688-A1 | Semicarbazide derivatives as kinase inhibitors | MERCK PATENT GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| US-20090253688-A1 | Semicarbazide derivatives as kinase inhibitors | MERCK PATENT GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253688-A1 | Semicarbazide derivatives as kinase inhibitors | MAP3K1, MAP3K6, MAP3K2 | GSK3B 324/4885DDR2 629/4885RAF1 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.