Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | RBP4 | P02753 | 3/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13648211 | 0.85 | PDK2 (0.40) | PDK2RBP4KDM4EGAAMAPK1 | |
| SCHEMBL13653261 | 0.81 | UTS2R (0.47) | KDM4EGAAMAPK1UTS2RRAF1 | |
| SCHEMBL13653309 | 0.80 | PDK2 (0.46) | PDK2CACNA1GCACNA1BCACNA1CKDM4E | |
| SCHEMBL19175612 | 0.79 | KDM4E (0.49) | PDK2KDM4EGAAMAPK1ALDH1A1 | |
| SCHEMBL14453647 | 0.79 | CA12 (0.44) | PDK2CACNA1BCACNA1C | |
| SCHEMBL4015052 | 0.77 | PDK2 (0.43) | PDK2KDM4EGAAMAPK1KAT6A | |
| SCHEMBL14431424 | 0.75 | PDK2 (0.43) | PDK2KDM4EGAAMAPK1ALDH1A1 | |
| SCHEMBL2146616 | 0.75 | PDK2 (0.46) | PDK2RBP4CACNA1GCACNA1BCACNA1C | |
| SCHEMBL21601484 | 0.74 | MAPK1 (0.51) | PDK2KDM4EGAAMAPK1ALDH1A1 | |
| SCHEMBL21601488 | 0.73 | KDM4E (0.55) | PDK2KDM4EGAAMAPK1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253688-A1 | Semicarbazide derivatives as kinase inhibitors | MERCK PATENT GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253688-A1 | Semicarbazide derivatives as kinase inhibitors | MAP3K1, MAP3K6, MAP3K2 | PDK2 79/4885RBP4 4817/4885CACNA1G 2752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.