Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 13/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | MAP3K6 | O95382 | 2/20 | 0.45 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1524348 | 0.87 | MAP3K5 (0.55) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1524126 | 0.86 | MAP3K5 (0.51) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1073271 | 0.85 | MAP3K5 (0.49) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1021743 | 0.85 | MAP3K5 (0.52) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1523604 | 0.84 | MAP3K5 (0.52) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1522805 | 0.84 | MAP3K5 (0.55) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL12838095 | 0.83 | MAP3K5 (0.55) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1524079 | 0.83 | MAP3K5 (0.56) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1523180 | 0.82 | MAP3K5 (0.47) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1523485 | 0.82 | MAP3K5 (0.55) | MAP3K5NPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123986-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | WO | disclosed |