Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13650589 | 0.80 | HRH3 (0.47) | HRH4HRH3 | |
| SCHEMBL13650591 | 0.80 | HRH3 (0.47) | HRH4HRH3 | |
| SCHEMBL13650593 | 0.72 | HRH3 (0.47) | HRH4HRH3 | |
| SCHEMBL13650592 | 0.72 | HRH3 (0.47) | HRH4HRH3 | |
| SCHEMBL13650586 | 0.69 | HRH3 (0.45) | HRH4HRH3KDM1A | |
| SCHEMBL13650554 | 0.66 | HRH3 (0.46) | HRH4HRH3KDM1A | |
| SCHEMBL13650552 | 0.65 | HRH3 (0.47) | HRH4HRH3 | |
| SCHEMBL13650664 | 0.65 | HRH4 (0.53) | HRH4HRH3 | |
| SCHEMBL13650667 | 0.65 | HRH3 (0.45) | HRH4HRH3 | |
| SCHEMBL13650665 | 0.65 | HRH3 (0.45) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123967-A1 | 5,6,7,8-TETRAHYDROQUINAZOLIN-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H4 RECEPTOR MODULATORS FOR THE TREATMENT OF ASTHMA | ABBOTT LABORATORIES (US) | 2009-10-08 | — | — | WO | disclosed |