Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.81 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.76 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.76 |
| ▸ | MTOR | P42345 | 1/20 | 0.76 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.76 |
| ▸ | PRKDC | P78527 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990091 | 0.92 | PIK3CA (0.81) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL989335 | 0.90 | PIK3CA (0.87) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL988858 | 0.90 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL988656 | 0.89 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL990459 | 0.86 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL13655393 | 0.86 | PIK3CA (0.90) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL989226 | 0.86 | PIK3CA (0.93) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL988531 | 0.86 | PIK3CA (0.89) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL989415 | 0.85 | PIK3CA (0.92) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL12535570 | 0.84 | PIK3CA (0.89) | PIK3CAPIK3CBPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |