Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.53 |
| ▸ | MAP3K14 | Q99558 | 6/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13655299 | 0.94 | PIK3CA (0.60) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL1931800 | 0.89 | PIK3CA (0.56) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL12535438 | 0.89 | PIK3CA (0.65) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL12535552 | 0.88 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL990106 | 0.85 | PIK3CA (0.58) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL12535430 | 0.83 | PIK3CA (0.56) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL13655393 | 0.76 | PIK3CA (0.90) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL987841 | 0.76 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL15663312 | 0.76 | PIK3CA (0.50) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL15663417 | 0.75 | PIK3CA (0.57) | PIK3CAPIK3CBPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |