Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.37 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13655325 | 0.87 | MC4R (0.40) | CHEK1PIP5K1CCDK7KDM4EMEN1 | |
| SCHEMBL13655332 | 0.87 | PIP5K1C (0.40) | CHEK1PIP5K1CCDK7KDM4EMEN1 | |
| SCHEMBL13655347 | 0.84 | ITK (0.39) | ITKCHEK1PIP5K1CPARP1CDK7 | |
| SCHEMBL13655345 | 0.82 | CLK2 (0.42) | ITKCHEK1PIP5K1CPARP1CDK7 | |
| SCHEMBL13655331 | 0.82 | KDM4E (0.43) | ITKCHEK1PIP5K1CCDK7KDM4E | |
| SCHEMBL13655330 | 0.81 | CLK2 (0.39) | CHEK1PIP5K1CCDK7CLK2CLK3 | |
| SCHEMBL13655336 | 0.79 | CHEK1 (0.46) | CHEK1PIP5K1CPARP1CDK7KDM4E | |
| SCHEMBL13655346 | 0.78 | CHEK1 (0.46) | CHEK1PIP5K1CCDK7CLK2CLK3 | |
| SCHEMBL27708381 | 0.75 | ITK (0.58) | ITKCHEK1CLK2CLK3DYRK1A | |
| SCHEMBL13655343 | 0.74 | CHEK1 (0.45) | ITKCHEK1PIP5K1CPARP1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247504-A1 | Indazole Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090247504-A1 | Indazole Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247504-A1 | Indazole Derivatives for Treatment of Alzheimer's Disease | MAPT, PSEN2, PSEN1 | TERT 634/4885CCNA2 1870/4885CDK2 511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.