Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989483 | 0.80 | NOTUM (0.70) | NOTUMPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL989543 | 0.80 | NOTUM (0.52) | NOTUMPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL15173259 | 0.79 | NOTUM (0.55) | NOTUMPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL991030 | 0.78 | NOTUM (0.56) | NOTUMPIK3CAPIK3CB | |
| SCHEMBL17302376 | 0.77 | NOTUM (0.53) | NOTUMPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL988994 | 0.77 | NOTUM (0.55) | NOTUMPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4235720 | 0.77 | NOTUM (0.55) | NOTUMPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL989482 | 0.76 | KDM4E (0.56) | NOTUMPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL988878 | 0.76 | NOTUM (0.55) | NOTUMPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL988463 | 0.71 | NOTUM (0.70) | NOTUMPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |