Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.82 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040216 | 0.90 | PIK3CA (1.00) | PIK3CAHSP90AA1PIK3CBPIK3CDPIK3CG | |
| SCHEMBL1041546 | 0.90 | PIK3CA (0.82) | PIK3CAHSP90AA1PIK3CBPIK3CDPIK3CG | |
| SCHEMBL1043569 | 0.89 | PIK3CA (1.00) | PIK3CAHSP90AA1PIK3CBPIK3CDPIK3CG | |
| SCHEMBL15663328 | 0.88 | PIK3CA (0.79) | PIK3CAHSP90AA1PIK3CBPIK3CDPIK3CG | |
| SCHEMBL988698 | 0.87 | PIK3CA (0.78) | PIK3CAHSP90AA1PIK3CBPIK3CDPIK3CG | |
| SCHEMBL1041985 | 0.87 | PIK3CA (0.88) | PIK3CAHSP90AA1PIK3CBPIK3CDPIK3CG | |
| SCHEMBL1040129 | 0.87 | PIK3CA (0.88) | PIK3CAHSP90AA1PIK3CBPIK3CDPIK3CG | |
| SCHEMBL12535364 | 0.85 | PIK3CA (0.73) | PIK3CAHSP90AA1PIK3CBPIK3CDPIK3CG | |
| SCHEMBL989593 | 0.85 | PIK3CA (0.83) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1041927 | 0.85 | PIK3CA (0.83) | PIK3CAHSP90AA1PIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |