Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989867 | 0.91 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL988635 | 0.86 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL989617 | 0.83 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL12535145 | 0.71 | PIK3CA (0.79) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL1484737 | 0.70 | NOTUM (0.57) | PIK3CAPIK3CB | |
| SCHEMBL1484678 | 0.68 | NOTUM (0.47) | PIK3CAPIK3CB | |
| SCHEMBL989011 | 0.68 | PIK3CA (0.70) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL12535925 | 0.67 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL988209 | 0.67 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL989466 | 0.67 | PIK3CA (0.82) | PIK3CAPIK3CBPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |