Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.64 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1038152 | 0.90 | PIK3CA (0.64) | PIK3CAEEDSUZ12EZH2PIK3CB | |
| SCHEMBL1043508 | 0.88 | PIK3CA (0.70) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1037445 | 0.87 | PIK3CA (0.61) | PIK3CAEEDSUZ12EZH2PIK3CB | |
| SCHEMBL1041579 | 0.81 | PIK3CA (0.81) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL989959 | 0.81 | PIK3CA (0.67) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL989355 | 0.81 | PIK3CA (0.56) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| Hydrochloric Acid SCHEMBL1081966 | 0.81 | PIK3CA (0.80) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL990678 | 0.79 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CG | |
| SCHEMBL1038805 | 0.78 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1040000 | 0.78 | PIK3CA (0.55) | PIK3CAPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |