Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.64 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.64 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13687980 | 0.85 | PARP1 (0.62) | PARP1CSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL10132659 | 0.85 | PARP1 (0.69) | PARP1CSNK2A1CSNK2A2CSNK2BIMPDH2 | |
| SCHEMBL10132620 | 0.84 | PARP1 (0.64) | PARP1CSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL10132666 | 0.83 | PARP1 (0.66) | PARP1CSNK2A1CSNK2A2CSNK2BIMPDH2 | |
| SCHEMBL10132633 | 0.82 | PARP1 (0.65) | PARP1CSNK2A1CSNK2A2CSNK2BIMPDH2 | |
| SCHEMBL10132586 | 0.82 | PARP1 (0.61) | PARP1CSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL10132625 | 0.82 | PARP1 (0.61) | PARP1CSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL13648691 | 0.82 | PARP1 (0.71) | PARP1CSNK2A1CSNK2A2CSNK2BIMPDH2 | |
| SCHEMBL10132580 | 0.81 | PARP1 (0.60) | PARP1CSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL10132650 | 0.80 | PARP1 (0.59) | PARP1CSNK2A1CSNK2A2CSNK2BIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264423-A2 | SERINE-THREONINE PROTEIN KINASE AND PARP MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264423-A2 | SERINE-THREONINE PROTEIN KINASE AND PARP MODULATORS | PACSIN2, TNKS, PARP1 | PARP1 3/4885CSNK2A1 24/4885CSNK2A2 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.