Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 18/20 | 0.52 |
| ▸ | RAMP1 | O60894 | 4/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087424 | 0.88 | CALCRL (0.55) | CALCRLRAMP1 | |
| SCHEMBL2165841 | 0.87 | CALCRL (0.52) | CALCRLRAMP1 | |
| SCHEMBL29872287 | 0.87 | CALCRL (0.52) | CALCRLRAMP1 | |
| SCHEMBL12622797 | 0.86 | CALCRL (0.52) | CALCRLRAMP1 | |
| SCHEMBL10330728 | 0.86 | CALCRL (0.52) | CALCRLRAMP1 | |
| SCHEMBL1700379 | 0.85 | CHRM2 (0.50) | CALCRLRAMP1 | |
| SCHEMBL3960086 | 0.85 | CALCRL (0.55) | CALCRLRAMP1 | |
| SCHEMBL19874018 | 0.84 | CALCRL (0.54) | CALCRLRAMP1 | |
| SCHEMBL10024352 | 0.84 | CALCRL (0.49) | CALCRLRAMP1 | |
| SCHEMBL15144550 | 0.84 | CALCRL (0.48) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108648-A1 | Selected CGRP antagonists, method for their manufacture and use as medicines | Boehringer Ingelheim International GmbH (DE) | 2009-10-14 | — | — | EP | disclosed |
| EP-1732917-B1 | SELECTED CGRP ANTAGONISTS, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-07-29 | — | — | EP | disclosed |