Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 12/20 | 0.44 |
| ▸ | RAMP1 | O60894 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16313925 | 0.88 | MAPT (0.47) | CALCRLRAMP1NPC1MAPK13MAPK12 | |
| SCHEMBL30178303 | 0.85 | HTR2C (0.49) | CALCRLRAMP1NPC1MAPK13MAPK12 | |
| SCHEMBL651023 | 0.85 | HTR2C (0.49) | CALCRLRAMP1NPC1MAPK13MAPK12 | |
| SCHEMBL3278838 | 0.85 | CALCRL (0.44) | CALCRLRAMP1NPC1MAPK13MAPK12 | |
| SCHEMBL1700379 | 0.85 | CHRM2 (0.50) | CALCRLRAMP1NPC1MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL1819629 | 0.84 | HTR2C (0.48) | CALCRLRAMP1NPC1MAPK13MAPK12 | |
| SCHEMBL12401887 | 0.84 | CALCRL (0.46) | CALCRLRAMP1NPC1MAPK13MAPK12 | |
| SCHEMBL15144550 | 0.84 | CALCRL (0.48) | CALCRLRAMP1NPC1MAPK13MAPK12 | |
| SCHEMBL4718744 | 0.83 | CALCRL (0.45) | CALCRLRAMP1NPC1MAPK13MAPK12 | |
| SCHEMBL4718740 | 0.82 | CALCRL (0.44) | CALCRLRAMP1NPC1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108648-A1 | Selected CGRP antagonists, method for their manufacture and use as medicines | Boehringer Ingelheim International GmbH (DE) | 2009-10-14 | — | — | EP | disclosed |