Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13656170 | 1.00 | POLB (0.45) | POLBSIGMAR1PIK3CDCHRM5CHRM1 | |
| SCHEMBL13656168 | 0.98 | POLB (0.46) | POLBSIGMAR1PIK3CDCHRM5CHRM1 | |
| SCHEMBL23023701 | 0.89 | POLB (0.51) | POLBSIGMAR1PIK3CDCHRM5CHRM1 | |
| SCHEMBL18021940 | 0.89 | POLB (0.51) | POLBSIGMAR1PIK3CDCHRM5CHRM1 | |
| SCHEMBL12726849 | 0.89 | HRH3 (0.42) | PIK3CDHRH3ALDH1A1TSHRRECQL | |
| SCHEMBL21107438 | 0.87 | POLB (0.46) | POLBSIGMAR1PIK3CDCHRM5CHRM1 | |
| SCHEMBL21105875 | 0.87 | POLB (0.46) | POLBSIGMAR1PIK3CDCHRM5CHRM1 | |
| SCHEMBL22861852 | 0.87 | POLB (0.46) | POLBSIGMAR1PIK3CDCHRM5CHRM1 | |
| SCHEMBL13656174 | 0.86 | MEN1 (0.41) | PIK3CDHRH3ALDH1A1TSHRRECQL | |
| SCHEMBL3422771 | 0.86 | PIK3CD (0.44) | POLBSIGMAR1PIK3CDCHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3715343-A1 | DIPHENYLAMINOPYRIMIDINE COMPOUND FOR INHIBITING KINASE ACTIVITY | Shenzhen TargetRx, Inc. (CN) | 2020-09-30 | — | — | EP | disclosed |
| US-7605176-B2 | β-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-20 | — | — | US | disclosed |
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |