Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 5/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12437178 | 0.89 | KCNH2 (0.53) | MAOBKDM4ECNR2TSHRMAPK1 | |
| SCHEMBL10287670 | 0.86 | BCHE (0.48) | MAOBKDM4ECNR2TSHRMAPK1 | |
| SCHEMBL22749466 | 0.82 | MAOB (0.57) | MAOBKDM4ECNR2TSHRMAPK1 | |
| SCHEMBL27342559 | 0.82 | BCHE (0.55) | MAOBKDM4EBCHEACHEAPP | |
| SCHEMBL9283313 | 0.81 | CNR2 (0.52) | MAOBKDM4ECNR2TSHRMAPK1 | |
| Chloromethane SCHEMBL27279686 | 0.81 | HRH3 (0.53) | MAOBKDM4ECNR2TSHRMAPK1 | |
| SCHEMBL9286253 | 0.80 | HRH3 (0.57) | MAOBKDM4ECNR2TSHRMAPK1 | |
| Chloromethane SCHEMBL27279684 | 0.80 | HRH3 (0.60) | MAOBKDM4ECNR2TSHRMAPK1 | |
| SCHEMBL12788511 | 0.80 | MEN1 (0.43) | TSHRBCHEACHECYP2D6CYP2C19 | |
| SCHEMBL81248 | 0.80 | HRH3 (0.65) | MAOBKDM4ECNR2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605176-B2 | β-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-20 | — | — | US | disclosed |
| US-7605176-B2 | β-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-20 | — | — | US | disclosed |