Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017289 | 0.85 | CHUK (0.44) | CHUKKMT2AJAK3BTK | |
| SCHEMBL1015217 | 0.84 | KMT2A (0.51) | CHUKKMT2AADORA3ADORA1ADORA2A | |
| SCHEMBL1020910 | 0.83 | CHUK (0.45) | CHUKKMT2AADORA3ADORA1ADORA2A | |
| SCHEMBL30861039 | 0.79 | CHUK (0.42) | CHUKKMT2AJAK3BTK | |
| SCHEMBL24059429 | 0.77 | IRAK4 (0.49) | CHUKKMT2AAXLPDE4A | |
| SCHEMBL22280370 | 0.73 | IRAK4 (0.54) | CHUKKMT2A | |
| SCHEMBL20343974 | 0.73 | CHUK (0.65) | CHUKJAK3BTK | |
| Hydrochloric Acid SCHEMBL22496920 | 0.72 | CCNT1 (0.42) | JAK3 | |
| Hydrochloric Acid SCHEMBL22496922 | 0.72 | CCNT1 (0.42) | JAK3 | |
| SCHEMBL13666810 | 0.71 | CHUK (0.38) | CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |