Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | POLRMT | O00411 | 1/20 | 0.32 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gs-441524 SCHEMBL10120689 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT | |
| Gs-441524 SCHEMBL10120691 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT | |
| Gs-441524 SCHEMBL22142944 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT | |
| Gs-441524 SCHEMBL24667691 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT | |
| Gs-441524 SCHEMBL15998246 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT | |
| Gs-441524 SCHEMBL24975226 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT | |
| Gs-441524 SCHEMBL22096285 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT | |
| Gs-441524 SCHEMBL23870459 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT | |
| Gs-441524 SCHEMBL22663744 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT | |
| Gs-441524 SCHEMBL31174011 | 0.91 | TMPRSS2 (0.60) | TMPRSS2ADORA2ACDK5CDK5R1POLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132135-A1 | 1' -SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2009-10-29 | — | — | WO | disclosed |