Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 20/20 | 0.80 |
| ▸ | EGFR | P00533 | 4/20 | 0.80 |
| ▸ | MET | P08581 | 4/20 | 0.80 |
| ▸ | SRC | P12931 | 4/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12704879 | 0.93 | AXL (0.79) | AXLEGFRMETSRC | |
| SCHEMBL13667484 | 0.89 | AXL (0.74) | AXLEGFRMETSRC | |
| SCHEMBL1591312 | 0.89 | AXL (1.00) | AXLEGFRMETSRC | |
| SCHEMBL13667271 | 0.88 | AXL (0.66) | AXLEGFRMETSRC | |
| SCHEMBL1554539 | 0.88 | AXL (0.90) | AXLEGFRMETSRC | |
| SCHEMBL10328505 | 0.87 | AXL (0.73) | AXLEGFRMETSRC | |
| SCHEMBL1556013 | 0.87 | AXL (0.91) | AXLEGFRMETSRC | |
| SCHEMBL13667531 | 0.86 | AXL (0.60) | AXLEGFRMETSRC | |
| SCHEMBL12709293 | 0.85 | AXL (0.78) | AXLEGFRMETSRC | |
| SCHEMBL1546591 | 0.85 | AXL (0.88) | AXLEGFRMETSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127417-A1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2009-10-22 | — | — | WO | disclosed |