Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 18/20 | 1.00 |
| ▸ | CDK2 | P24941 | 10/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.58 |
| ▸ | CCNH | P51946 | 8/20 | 0.58 |
| ▸ | CDK9 | P50750 | 6/20 | 0.58 |
| ▸ | CDK1 | P06493 | 6/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.58 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.58 |
| ▸ | CDK4 | P11802 | 4/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.58 |
| ▸ | CDK8 | P49336 | 3/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.58 |
| ▸ | CCND1 | P24385 | 2/20 | 0.58 |
| ▸ | INSRR | P14616 | 1/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366787 | 1.00 | CDK7 (1.00) | CDK7CDK2CCNE1CCNHCDK9 | |
| SCHEMBL12143254 | 1.00 | CDK7 (1.00) | CDK7CDK2CCNE1CCNHCDK9 | |
| SCHEMBL1367348 | 0.91 | CDK7 (0.83) | CDK7CDK2CCNE1CCNHCDK9 | |
| SCHEMBL1367345 | 0.91 | CDK7 (0.83) | CDK7CDK2CCNE1CCNHCDK9 | |
| SCHEMBL1370025 | 0.91 | CDK7 (0.83) | CDK7CDK2CCNE1CCNHCDK9 | |
| SCHEMBL1368215 | 0.91 | CDK7 (0.82) | CDK7CDK2CCNE1CCNHCDK9 | |
| SCHEMBL12143314 | 0.90 | CDK7 (0.81) | CDK7CDK2CCNE1CCNHCDK9 | |
| SCHEMBL12143292 | 0.90 | CDK7 (0.81) | CDK7CDK2CCNE1CCNHCDK9 | |
| SCHEMBL12143317 | 0.89 | CDK7 (0.82) | CDK7CDK2CCNE1CCNHCDK9 | |
| SCHEMBL12143295 | 0.89 | CDK7 (0.82) | CDK7CDK2CCNE1CCNHCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067424-B2 | Selective inhibitors for cyclin-dependent kinases | EMORY UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067424-B2 | Selective inhibitors for cyclin-dependent kinases | EMORY UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067424-B2 | Selective inhibitors for cyclin-dependent kinases | EMORY UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-20100261683-A1 | Selective Inhibitors for Cyclin-Dependent Kinases | EMORY UNIVERSITY | 2010-10-14 | — | — | US | disclosed |
| US-20100261683-A1 | Selective Inhibitors for Cyclin-Dependent Kinases | EMORY UNIVERSITY | 2010-10-14 | — | — | US | disclosed |
| US-20100261683-A1 | Selective Inhibitors for Cyclin-Dependent Kinases | EMORY UNIVERSITY | 2010-10-14 | — | — | US | disclosed |
| WO-2008151304-A1 | SELECTIVE INHIBITORS FOR CYCLIN-DEPENDENT KINASES | EMORY UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261683-A1 | Selective Inhibitors for Cyclin-Dependent Kinases | CDK7, CCNK, CDK17 | CDK7 1/4885CDK2 5/4885CCNE1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.