Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GPR6 | P46095 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606197 | 0.86 | NPC1 (0.60) | KMT2ACHRNA4MAPTALDH1A1TSHR | |
| SCHEMBL2603239 | 0.82 | KMT2A (0.56) | KMT2ACHRNA4MAPTALDH1A1TSHR | |
| SCHEMBL25676108 | 0.82 | KMT2A (0.56) | KMT2ACHRNA4MAPTALDH1A1TSHR | |
| SCHEMBL13631422 | 0.82 | KMT2A (0.66) | KMT2ACHRNA4MAPTALDH1A1TSHR | |
| SCHEMBL23573417 | 0.81 | KMT2A (0.54) | KMT2ACHRNA4MAPTALDH1A1TSHR | |
| SCHEMBL1082421 | 0.80 | KMT2A (0.56) | KMT2ACHRNA4MAPTALDH1A1TSHR | |
| SCHEMBL1023268 | 0.80 | KMT2A (0.53) | KMT2ACHRNA4MAPTALDH1A1TSHR | |
| SCHEMBL4336905 | 0.80 | KMT2A (0.53) | KMT2ACHRNA4MAPTALDH1A1TSHR | |
| SCHEMBL2360551 | 0.80 | KMT2A (0.62) | KMT2ACHRNA4MAPTALDH1A1TSHR | |
| SCHEMBL18483472 | 0.80 | KMT2A (0.67) | KMT2ACHRNA4MAPTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |