Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.72 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.53 |
| ▸ | RAMP3 | O60896 | 1/20 | 0.47 |
| ▸ | CALCR | P30988 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12921132 | 0.91 | CALCRL (0.84) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL10071224 | 0.91 | CALCRL (0.72) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL6368025 | 0.91 | CALCRL (0.85) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL6341518 | 0.89 | CALCRL (0.84) | CALCRL | |
| SCHEMBL6342997 | 0.89 | CALCRL (0.84) | CALCRL | |
| SCHEMBL12028269 | 0.89 | CALCRL (0.84) | CALCRL | |
| SCHEMBL12948248 | 0.88 | CALCRL (0.72) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL12921137 | 0.87 | CALCRL (0.70) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL6343782 | 0.85 | CALCRL (0.84) | CALCRLRAMP1 | |
| SCHEMBL12921125 | 0.85 | CALCRL (0.84) | CALCRLRAMP1RAMP3CALCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120652-A2 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2009-10-01 | — | — | WO | disclosed |