Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.88 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.62 |
| ▸ | HTR6 | P50406 | 1/20 | 0.62 |
| ▸ | CES2 | O00748 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13676955 | 0.94 | GRM5 (0.85) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL3830983 | 0.94 | GRM5 (1.00) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL3835441 | 0.92 | GRM5 (0.85) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL3835520 | 0.92 | GRM5 (0.85) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL13676958 | 0.92 | GRM5 (0.81) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL13677012 | 0.91 | GRM5 (0.83) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL3834114 | 0.91 | GRM5 (0.90) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL3831682 | 0.91 | GRM5 (0.79) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL13677003 | 0.90 | GRM5 (0.82) | GRM5HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL13676946 | 0.90 | GRM5 (0.88) | GRM5HTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270371-A1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | RICHTER GEDEON NYRT. (HU) | 2009-10-29 | — | — | US | disclosed |
| US-20090270371-A1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | RICHTER GEDEON NYRT. (HU) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270371-A1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | GRM5, GRIK5, GRM1 | GRM5 1/4885HTR1A 63/4885HTR2A 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.