Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GCK | P35557 | 11/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1793221 | 0.85 | KMT2A (0.49) | KMT2ARXRARXRBALDH1A1GCK | |
| SCHEMBL151012 | 0.80 | KMT2A (0.64) | KMT2ARXRARXRBALDH1A1GCK | |
| SCHEMBL2563350 | 0.78 | KMT2A (0.50) | KMT2ARXRARXRBALDH1A1GCK | |
| SCHEMBL13870168 | 0.77 | KMT2A (0.46) | KMT2ARXRARXRBALDH1A1GCK | |
| SCHEMBL17060010 | 0.77 | KMT2A (0.64) | KMT2ARXRARXRBALDH1A1GCK | |
| SCHEMBL2666313 | 0.75 | PPARA (0.41) | KMT2ARXRARXRBALDH1A1GCK | |
| SCHEMBL2657806 | 0.74 | KMT2A (0.56) | KMT2ARXRARXRBALDH1A1GCK | |
| SCHEMBL18311267 | 0.74 | KMT2A (0.56) | KMT2ARXRARXRBALDH1A1GCK | |
| SCHEMBL15445136 | 0.73 | PPARA (0.52) | KMT2AALDH1A1MEN1KDM4ECYP2C9 | |
| SCHEMBL14190690 | 0.73 | PPARA (0.40) | KMT2ARXRARXRBALDH1A1GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1568367-B3 | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2009-09-02 | — | — | EP | disclosed |