Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 5/20 | 0.48 |
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | UTRN | P46939 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868373 | 0.83 | PTPN1 (0.51) | PTPN1IKBKBLMNATHRBPPARD | |
| SCHEMBL20861471 | 0.80 | PPARA (0.53) | PTPN1IKBKBLMNATHRBPPARD | |
| SCHEMBL2517496 | 0.80 | PPARA (0.49) | PTPN1IKBKBLMNATHRBPPARD | |
| SCHEMBL6221689 | 0.80 | PTPN1 (0.49) | PTPN1IKBKBLMNATHRBPPARD | |
| SCHEMBL12151275 | 0.80 | PPARD (0.56) | PTPN1IKBKBLMNATHRBPPARD | |
| SCHEMBL5543997 | 0.79 | NPC1 (0.52) | NOTUMNPC1KDM4EHPGDRAB9A | |
| SCHEMBL3737979 | 0.79 | IKBKB (0.49) | PTPN1IKBKBLMNATHRBPPARD | |
| SCHEMBL4432682 | 0.79 | IKBKB (0.49) | PTPN1IKBKBLMNATHRBPPARD | |
| SCHEMBL2245562 | 0.79 | PPARD (0.55) | PTPN1IKBKBLMNATHRBPPARD | |
| SCHEMBL9831925 | 0.79 | PTPN1 (0.51) | PTPN1IKBKBLMNATHRBPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638963-B1 | N-ACYL NITROGEN HETEROCYCLES AS LIGANDS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS | NOVARTIS AG (CH) | 2009-09-09 | — | — | EP | disclosed |
| EP-1448523-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | NOVARTIS AG (CH) | 2007-08-22 | — | — | EP | disclosed |