Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14615285 | 0.88 | MAPT (0.73) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL14642393 | 0.88 | TP53 (0.72) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL13679584 | 0.87 | TP53 (0.65) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL14642416 | 0.86 | MAPT (0.79) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL14615287 | 0.86 | TP53 (0.62) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL13679545 | 0.85 | KDR (0.66) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL13679711 | 0.83 | TP53 (0.74) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL14615294 | 0.82 | MAPT (0.61) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL14642405 | 0.82 | MAPT (0.73) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL14615298 | 0.82 | MAPT (0.72) | MAPTLMNAMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |