Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.73 |
| ▸ | EGFR | P00533 | 4/20 | 0.73 |
| ▸ | LCK | P06239 | 2/20 | 0.73 |
| ▸ | RET | P07949 | 1/20 | 0.73 |
| ▸ | KIF5B | P33176 | 1/20 | 0.73 |
| ▸ | CSF1R | P07333 | 2/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | FLT4 | P35916 | 1/20 | 0.67 |
| ▸ | FLT3 | P36888 | 1/20 | 0.67 |
| ▸ | BRAF | P15056 | 2/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.61 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18158553 | 0.97 | KDR (0.70) | KDREGFRLCKRETKIF5B | |
| SCHEMBL4023315 | 0.91 | PDGFRB (0.75) | KDREGFRLCKRETKIF5B | |
| SCHEMBL17278108 | 0.90 | KDM1A (0.73) | KDREGFRLCKRETKIF5B | |
| SCHEMBL4025375 | 0.89 | KDR (0.67) | KDREGFRLCKRETKIF5B | |
| SCHEMBL7214444 | 0.89 | KDR (0.63) | KDREGFRLCKRETKIF5B | |
| SCHEMBL4359665 | 0.87 | CSF1R (0.81) | KDREGFRLCKRETKIF5B | |
| SCHEMBL7209956 | 0.87 | KDR (0.58) | KDREGFRLCKRETKIF5B | |
| SCHEMBL7452950 | 0.87 | PDGFRB (0.66) | KDREGFRLCKRETKIF5B | |
| SCHEMBL4373197 | 0.86 | KDM1A (0.76) | KDREGFRLCKRETKIF5B | |
| SCHEMBL20229657 | 0.86 | KDR (0.74) | KDREGFRLCKRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3147281-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2017-03-29 | — | — | EP | disclosed |
| EP-2947072-A1 | 1-(3-(6,7-DIMETHOXYQUINAZOLIN-4-YLOXY)PHENYL)-3-(5-(1,1,1-TRIFLUORO-2-METHYLPROPAN-2-YL)ISOXAZOL-3-YL)UREA AS RAF KINASE MODULATOR IN THE TREATMENT OF CANCER DISEASES | Ambit Biosciences Corporation (US) | 2015-11-25 | — | — | EP | disclosed |
| EP-2268623-B1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORP (US) | 2015-05-06 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |