Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.81 |
| ▸ | RAF1 | P04049 | 6/20 | 0.72 |
| ▸ | KDR | P35968 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012483 | 0.90 | BRAF (1.00) | BRAFRAF1KDR | |
| SCHEMBL1780599 | 0.84 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL13680222 | 0.83 | BRAF (0.83) | BRAFRAF1KDR | |
| SCHEMBL19916632 | 0.79 | BRAF (0.73) | BRAFRAF1KDR | |
| SCHEMBL13680212 | 0.79 | BRAF (0.83) | BRAFRAF1KDR | |
| SCHEMBL1012249 | 0.78 | BRAF (1.00) | BRAFRAF1KDR | |
| SCHEMBL1015091 | 0.77 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL1098391 | 0.77 | BRAF (0.67) | BRAFRAF1KDR | |
| SCHEMBL1012677 | 0.77 | BRAF (1.00) | BRAFRAF1KDR | |
| SCHEMBL1012993 | 0.76 | BRAF (1.00) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |