Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.62 |
| ▸ | MMP3 | P08254 | 5/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 11/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848969 | 1.00 | TUBB1 (0.62) | TUBB1MMP3MMP1MMP9MMP8 | |
| SCHEMBL57221 | 1.00 | TUBB1 (0.62) | TUBB1MMP3MMP1MMP9MMP8 | |
| SCHEMBL89243 | 1.00 | TUBB1 (0.62) | TUBB1MMP3MMP1MMP9MMP8 | |
| SCHEMBL14233245 | 0.93 | TUBB1 (0.62) | TUBB1MMP3MMP1MMP9MMP8 | |
| SCHEMBL88936 | 0.91 | TUBB1 (0.60) | TUBB1MMP3MMP1MMP9MMP8 | |
| SCHEMBL14233799 | 0.91 | TUBB1 (0.60) | TUBB1MMP3MMP1MMP9MMP8 | |
| SCHEMBL58648 | 0.91 | TUBB1 (0.66) | TUBB1MMP3MMP1MMP9MMP8 | |
| SCHEMBL12202761 | 0.91 | TUBB1 (0.66) | TUBB1MMP3MMP1MMP9MMP8 | |
| SCHEMBL57789 | 0.91 | TUBB1 (0.66) | TUBB1MMP3MMP1MMP9MMP8 | |
| SCHEMBL88735 | 0.91 | TUBB1 (0.66) | TUBB1MMP3MMP1MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633224-B2 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | EISAI CO., LTD. (JP) | 2014-01-21 | — | — | US | disclosed |