Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311147 | 0.73 | MAPK1 (0.52) | MAPK1HTTFGFR1ALDH1A1KDM4E | |
| SCHEMBL18803510 | 0.71 | RPS6KA5 (0.67) | MAPK1HTTFGFR1ALDH1A1KDM4E | |
| SCHEMBL16200198 | 0.70 | PAK1 (0.38) | — | |
| SCHEMBL23840275 | 0.69 | FGFR1 (0.58) | HTTFGFR1ALDH1A1POLBMKNK1 | |
| SCHEMBL10094729 | 0.69 | MAPK1 (0.59) | MAPK1HTTFGFR1ALDH1A1KDM4E | |
| SCHEMBL13184345 | 0.69 | MAPK1 (0.48) | MAPK1HTTFGFR1ALDH1A1KDM4E | |
| SCHEMBL13826706 | 0.69 | HTT (0.60) | MAPK1HTTFGFR1ALDH1A1KDM4E | |
| SCHEMBL16140386 | 0.68 | RPS6KA5 (0.67) | MKNK1MKNK2 | |
| SCHEMBL12138417 | 0.66 | HTT (0.56) | MAPK1HTTFGFR1KDM4EPOLB | |
| SCHEMBL7211112 | 0.66 | HTT (0.56) | HTTFGFR1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |