Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316424 | 0.76 | NR2F2 (0.38) | DYRK1A | |
| SCHEMBL13184177 | 0.74 | HCAR2 (0.44) | DYRK1A | |
| SCHEMBL3464161 | 0.74 | HCAR2 (0.44) | DYRK1A | |
| SCHEMBL16800437 | 0.74 | CDK8 (0.33) | DYRK1A | |
| SCHEMBL16798178 | 0.67 | MAPT (0.44) | — | |
| SCHEMBL112351 | 0.66 | — | — | |
| SCHEMBL16200056 | 0.66 | — | — | |
| SCHEMBL13184398 | 0.65 | — | — | |
| SCHEMBL2735688 | 0.62 | — | — | |
| SCHEMBL13683076 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |