Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 16/20 | 0.54 |
| ▸ | HTR2C | P28335 | 16/20 | 0.54 |
| ▸ | HTR2B | P41595 | 16/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184325 | 0.85 | HTR2A (0.57) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL14043930 | 0.79 | HTR2A (0.47) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL13683092 | 0.78 | HTR2A (0.57) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL14044158 | 0.77 | HTR2A (0.53) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL2074027 | 0.76 | HTR2A (0.83) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL1475754 | 0.70 | HTR2C (1.00) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL2075780 | 0.69 | HTR2C (0.82) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL14693988 | 0.69 | HTR2A (0.53) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL1476540 | 0.68 | HTR2C (0.70) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL1475390 | 0.67 | HTR2A (0.74) | HTR2AHTR2CHTR2BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |