Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 19/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13069014 | 0.91 | GRM5 (0.74) | GRM5 | |
| SCHEMBL13684039 | 0.91 | GRM5 (0.67) | GRM5 | |
| SCHEMBL13684126 | 0.91 | GRM5 (0.68) | GRM5 | |
| SCHEMBL13684127 | 0.90 | GRM5 (0.73) | GRM5 | |
| SCHEMBL13684038 | 0.90 | GRM5 (0.71) | GRM5 | |
| SCHEMBL13684043 | 0.89 | GRM5 (0.69) | GRM5 | |
| SCHEMBL13684058 | 0.89 | GRM5 (0.59) | GRM5 | |
| SCHEMBL13683864 | 0.88 | GRM5 (0.69) | GRM5 | |
| SCHEMBL13684139 | 0.88 | GRM5 (0.58) | GRM5 | |
| SCHEMBL13683894 | 0.87 | GRM5 (0.63) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592337-B2 | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592337-B2 | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2009-09-22 | — | — | US | disclosed |