Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 19/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683936 | 0.87 | GRM5 (0.76) | GRM5 | |
| SCHEMBL13684140 | 0.85 | GRM5 (0.70) | GRM5 | |
| SCHEMBL13683864 | 0.84 | GRM5 (0.69) | GRM5 | |
| SCHEMBL13683876 | 0.84 | GRM5 (0.66) | GRM5 | |
| SCHEMBL13684040 | 0.84 | GRM5 (0.66) | GRM5 | |
| SCHEMBL13683888 | 0.83 | GRM5 (0.67) | GRM5 | |
| SCHEMBL13684054 | 0.83 | GRM5 (0.65) | GRM5 | |
| SCHEMBL13684144 | 0.83 | GRM5 (0.71) | GRM5 | |
| SCHEMBL13684051 | 0.83 | GRM5 (0.64) | GRM5 | |
| SCHEMBL13684050 | 0.83 | GRM5 (0.65) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592337-B2 | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592337-B2 | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2009-09-22 | — | — | US | disclosed |