Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13500684 | 1.00 | PDE2A (0.37) | PDE2AADRB3GPR139KIF11ACACB | |
| SCHEMBL1473416 | 1.00 | PDE2A (0.37) | PDE2AADRB3GPR139KIF11ACACB | |
| SCHEMBL13685075 | 0.95 | TRPV1 (0.35) | PDE2AADRB3GPR139TRPV1 | |
| SCHEMBL1473099 | 0.91 | TRPV1 (0.37) | PDE2AADRB3GPR139KIF11ACACB | |
| SCHEMBL1473728 | 0.91 | TRPV1 (0.37) | PDE2AADRB3GPR139KIF11ACACB | |
| SCHEMBL1474231 | 0.90 | KDM4E (0.36) | PDE2AADRB3GPR139ACACBTRPV1 | |
| SCHEMBL1474213 | 0.89 | TRPV1 (0.39) | KIF11TRPV1 | |
| SCHEMBL13685635 | 0.89 | TRPV1 (0.39) | KIF11TRPV1 | |
| SCHEMBL12747970 | 0.89 | TRPV1 (0.39) | KIF11TRPV1 | |
| SCHEMBL1473733 | 0.89 | TRPV1 (0.39) | KIF11TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861359-B1 | N-(N-SULFONYLAMINOMETHYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF PAIN | PFIZER (US) | 2012-11-14 | — | — | EP | disclosed |