Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1473696 | 1.00 | CHRNA7 (0.47) | CHRNA7TRPV1IKBKBJAK2ROCK2 | |
| SCHEMBL1474300 | 0.90 | CHRNA7 (0.47) | CHRNA7TRPV1 | |
| SCHEMBL1474093 | 0.86 | CHRNA7 (0.46) | CHRNA7TRPV1 | |
| SCHEMBL27699470 | 0.84 | CHRNA7 (0.41) | CHRNA7IKBKBJAK2ROCK2JAK3 | |
| SCHEMBL1473593 | 0.83 | CHRNA7 (0.38) | CHRNA7TRPV1 | |
| SCHEMBL1473756 | 0.82 | CHRNA7 (0.41) | CHRNA7TRPV1 | |
| SCHEMBL12747866 | 0.82 | CHRNA7 (0.42) | CHRNA7TRPV1 | |
| SCHEMBL1474131 | 0.82 | CHRNA7 (0.42) | CHRNA7TRPV1 | |
| SCHEMBL13622421 | 0.82 | CHRNA7 (0.42) | CHRNA7TRPV1 | |
| SCHEMBL1473592 | 0.82 | KCNH2 (0.48) | CHRNA7TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861359-B1 | N-(N-SULFONYLAMINOMETHYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF PAIN | PFIZER (US) | 2012-11-14 | — | — | EP | disclosed |