Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 4/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31404120 | 0.73 | PDK2 (0.50) | PDK2PDK4PDK1PDK3GSK3B | |
| SCHEMBL2268820 | 0.73 | PDK2 (0.50) | PDK2PDK4PDK1PDK3GSK3B | |
| SCHEMBL18850849 | 0.69 | MARK3 (0.44) | PDK2PDK4PDK1PDK3LCK | |
| SCHEMBL31219658 | 0.68 | MARK3 (0.43) | PDK2PDK4PDK1PDK3LCK | |
| SCHEMBL23097108 | 0.66 | PDK2 (0.47) | PDK2PDK4PDK1PDK3LCK | |
| SCHEMBL22643957 | 0.66 | MAP3K11 (0.38) | PDK2PDK4MARK3PDE3BPDE3A | |
| SCHEMBL18850912 | 0.66 | MARK3 (0.41) | PDK2PDK4PDK1PDK3LCK | |
| SCHEMBL22643897 | 0.66 | PDK2 (0.40) | PDK2PDK4MARK3PDE3BPDE3A | |
| SCHEMBL2453230 | 0.61 | MARK3 (0.44) | PDK2PDK4PDK1PDK3MARK3 | |
| SCHEMBL13748221 | 0.61 | PLK4 (0.33) | PLK4AURKACHEK2LCKCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595338-B2 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2009-09-29 | — | — | US | disclosed |