Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31472193 | 0.77 | TNKS (0.50) | HTR5ATNKSTNKS2HDAC4 | |
| SCHEMBL3866633 | 0.77 | TNKS (0.50) | HTR5ATNKSTNKS2HDAC4 | |
| SCHEMBL31472145 | 0.70 | TNKS (0.51) | TNKSTNKS2HDAC4 | |
| SCHEMBL15004855 | 0.70 | TNKS (0.51) | TNKSTNKS2HDAC4 | |
| SCHEMBL24481758 | 0.70 | TNKS (0.51) | HTR5ATNKSTNKS2HDAC4 | |
| SCHEMBL23591435 | 0.69 | BACE1 (0.44) | HTR5A | |
| SCHEMBL4719403 | 0.69 | TNKS (0.50) | TNKSTNKS2HDAC4 | |
| SCHEMBL20954874 | 0.68 | BACE1 (0.51) | TNKSTNKS2 | |
| SCHEMBL15650376 | 0.67 | TNKS (0.46) | TNKSTNKS2HDAC4 | |
| SCHEMBL31414295 | 0.63 | TNKS (0.40) | TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595338-B2 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles | WYETH (US) | 2009-09-29 | — | — | US | disclosed |