Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 7/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368343 | 0.78 | CDK8 (0.47) | TNIKCDK8CDK7CCNT1CCND1 | |
| SCHEMBL1365527 | 0.74 | TNIK (0.49) | TNIKCDK8CDK7CCNT1CCND1 | |
| SCHEMBL4503280 | 0.74 | P4HTM (0.52) | TNIKBRD4PIK3CAMTORSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1369411 | 0.73 | TNIK (0.49) | TNIKCDK8CDK7CCNT1CCND1 | |
| SCHEMBL29072615 | 0.73 | TNIK (0.57) | TNIKBRD4CDK8CDK7PIK3CA | |
| SCHEMBL30580391 | 0.73 | TNIK (0.57) | TNIKBRD4CDK8CDK7PIK3CA | |
| SCHEMBL720887 | 0.72 | BRD4 (1.00) | TNIKBRD4CDK8PIK3CARIPK1 | |
| SCHEMBL29072546 | 0.71 | TNIK (0.57) | TNIKBRD4CDK8CDK7CCNT1 | |
| SCHEMBL30580401 | 0.71 | TNIK (0.57) | TNIKBRD4CDK8CDK7CCNT1 | |
| SCHEMBL1368092 | 0.71 | PIK3CA (0.48) | TNIKBRD4CDK8CDK7CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067599-B2 | Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2011-11-29 | — | — | US | claimed |
| US-8067599-B2 | Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2011-11-29 | — | — | US | disclosed |