Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18370275 | 0.81 | POLB (0.38) | POLBALDH1A1GAAKDM4ENPC1 | |
| SCHEMBL18369628 | 0.81 | POLB (0.38) | POLBALDH1A1GAAPIK3CDPIK3R1 | |
| SCHEMBL24616716 | 0.81 | SLC2A1 (0.43) | POLBALDH1A1GAAKDM4ETP53 | |
| Bromide SCHEMBL23088025 | 0.80 | POLB (0.37) | POLBALDH1A1GAAPIK3CDPIK3R1 | |
| SCHEMBL16686975 | 0.79 | MAPK14 (0.47) | POLBMAPK14ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13687352 | 0.78 | MAPK14 (0.58) | POLBMAPK14ALDH1A1KDM4E | |
| SCHEMBL11163453 | 0.77 | MAPK14 (0.52) | POLBMAPK14CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL13687333 | 0.75 | SCN5A (0.47) | POLBMAPK14SMN1; SMN2 | |
| SCHEMBL12510331 | 0.75 | CCNC (0.45) | POLBMAPK14ALDH1A1GAAPIK3CD | |
| SCHEMBL27455823 | 0.75 | PIM1 (0.55) | POLBMAPK14ALDH1A1GAAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592354-B2 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-22 | — | — | US | disclosed |