Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.57 |
| ▸ | SYK | P43405 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277530 | 0.92 | JAK3 (0.57) | JAK3SYKCYP2D6MAPK1JAK2 | |
| SCHEMBL1634076 | 0.92 | JAK3 (0.58) | JAK3SYKCYP2D6MAPK1JAK2 | |
| SCHEMBL2279878 | 0.90 | JAK3 (0.55) | JAK3SYKCYP2D6MAPK1JAK2 | |
| SCHEMBL2348644 | 0.90 | JAK3 (0.55) | JAK3SYKCYP2D6MAPK1JAK2 | |
| SCHEMBL2276633 | 0.89 | JAK3 (0.58) | JAK3SYKCYP2D6MAPK1JAK2 | |
| SCHEMBL2279840 | 0.88 | JAK3 (0.58) | JAK3SYKCYP2D6MAPK1JAK2 | |
| SCHEMBL12449857 | 0.88 | JAK3 (0.44) | JAK3SYKCYP2D6MAPK1JAK2 | |
| SCHEMBL2279651 | 0.87 | JAK3 (0.56) | JAK3SYKCYP2D6MAPK1JAK2 | |
| SCHEMBL2280912 | 0.86 | JAK3 (0.55) | JAK3SYKCYP2D6MAPK1JAK2 | |
| SCHEMBL2274976 | 0.85 | JAK3 (0.59) | JAK3SYKCYP2D6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |