Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.42 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13693136 | 0.93 | BRAF (0.40) | BRAFMAPK14RAF1MAPK13MAPK12 | |
| SCHEMBL13693132 | 0.91 | BRAF (0.44) | BRAFMAPK14RAF1MAPK13MAPK9 | |
| SCHEMBL13693365 | 0.86 | BRAF (0.53) | BRAFMAPK14RAF1 | |
| SCHEMBL13693366 | 0.85 | MAPK14 (0.44) | BRAFMAPK14RAF1MAPK13MAPK9 | |
| SCHEMBL13693454 | 0.84 | MAPK14 (0.42) | BRAFMAPK14RAF1MAPK13MAPK9 | |
| SCHEMBL13693361 | 0.83 | MAPK14 (0.44) | BRAFMAPK14RAF1MAPK13MAPK9 | |
| SCHEMBL13693130 | 0.80 | BRAF (0.37) | BRAFMAPK14RAF1MAPK13MAPK9 | |
| SCHEMBL84613 | 0.79 | BRAF (0.44) | BRAFMAPK14RAF1MAPK13MAPK9 | |
| SCHEMBL13693374 | 0.79 | MAPK9 (0.44) | BRAFMAPK14RAF1MAPK13MAPK9 | |
| SCHEMBL13693250 | 0.78 | CDK7 (0.39) | MAPK14RAF1MAPK13MAPK9MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115572-A2 | NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF | NOVARTIS AG (CH) | 2009-09-24 | — | — | WO | disclosed |